Diabetes and Lipid Clinic of Alaska




Niaspan is used tolower total cholesterol, LDL, Lp(a), and triglycerides, and raise HDL.

Dosage and administration:

Niaspan 500 mg. to 2000 mg. daily at bedtime. Niaspan® is started at a low close and Increased over time, which allows your body to get used to the niacin. In order to reduce “flushing” (i.e. warmth, redness, itching and/or tingling), we recommend that you takeNiaspan after a low-fat snack and at bedtime. If flushing occurs, it usually happens 2 to 4 hours after taking Niaspan and lasts about an hour. Taking an uncoated aspirin before or at the time of taking your Niaspan will often help reduce flushing as well (aspirin reduces prostaglandin production). You can take a coated aspirin at dinner. Flushing may occur temporarily when you first start taking this medicine or when you first increase the dose. A gradual increase in dose helps decrease flushing. Do not take Niaspan on an empty stomach. Eating spicy foods, and/or drinking alcohol, or hot liquids near the time that you take Niaspan may increase flushing. Niaspan is intended to be taken only at bedtime. Other prevenative measures include 1 tsp of Metamucil, yogurt or a few apple slices at the time of administration of Niaspan. To abort an attack of flushing, try a chewable aspirin.

Dose Schedule:
Week 1-4 Niaspan 500 mg.                              1 tablet at bedtime
Week 5-8 Niaspan 500 mg.                              2 tablets at bedtime
Different dose Niaspan tablets release drug over different lengths of time The 500mg tablet releases over 10 hours, the 1000mg tablet over 8 hours, and the 750mg tablet over about 9 1/2 hours. For this reason, your prescription will usually begin with 500mg tablets. When you have adjusted to the optimum dose of Niaspan the prescription can then be changed to a larger dose pill. Niaspan tablets should be taken whole, not broken, crushed, or chewed. The daily dosage of Niaspan should not be increased by more than 500 mg. in any 4 week period. You should only take the dose prescribed for you. Do not substitute any other niacin products or change dosage of this medication without consulting Dr Tanner

Please notify us if you have any problems with Niaspan or if you are taking vitamins/supplements containing more than 100 mg. of niacin. Your labs should be repeated after you have been taking 1000 mg of Niaspan for 4 weeks. It is important to have your blood tests done promptly when ordered so that your liver enzymes, as well as your cholesterol levels, can be monitored.

You should not take Niaspan if you have liver disease, active peptic ulcer, or a hypersensitivity to niacin.